Dapagliflozin: Reduced serum lithium conc. Decreased exposure w/ rifampicin. Increased exposure w/ mefenamic acid. Metformin: Potential interaction in renal tubular secretion w/ cationic drugs eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin. Decreased C
max & AUC of glibenclamide. Increased C
max & AUC w/ frusemide, nifedipine. Hyperglycemia w/ thiazides, other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca-channel blockers, INH.